Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors

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• 作者：Yan Yang¹ ; Ziyi Li¹ ; Xupeng Wu¹ ; Haolin Chen² ; ⁶ ; Wenting Xu³ ; Qi Xiang¹ ; ³ ; ⁴ ; Qihao Zhang¹ ; ⁴ ; Jie Chen⁵ ; Ren-Shan Ge⁶ ; Zhijian Su¹ ; ⁴ ; ^{tjnuszj@jnu.edu.cn} ; Yadong Huang¹ ; ³ ; ⁴ ; ^{tydhuang@jnu.edu.cn}
• 关键词：cell fate conversion ; fibroblast ; Leydig cell ; transcription factors
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：39-53
• 全文大小：6012 K
• 卷排序：8

文摘

Direct reprogramming of fibroblasts into Leydig cell fate by defined factors Induced Leydig-like cells (iLCs) exhibit adult Leydig cell characterizations Conversion process toward iLCs did not pass through a mitotic cell state Transplantation of iLCs could survive and function in the interstitium of testis