Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress
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- 作者：Megan Chastain1 ; Qing Zhou1 ; Olga Shiva1 ; Maria Fadri-Moskwik1 ; Leanne Whitmore2 ; Pingping Jia1 ; Xueyu Dai1 ; Chenhui Huang1 ; Ping Ye3 ; 4 ; Weihang Chai1 ; wchai@wsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTC1/STN1/TEN1 ; replication stress ; RAD51 ; genome stability
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1300-1314
- 全文大小：4904 K
文摘
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STN1 is enriched at GC-rich repetitive sequences in response to replication stress
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STN1 suppression exacerbates the fragility of these sequences under replication stress
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CST interacts with RAD51 in an ATR-dependent manner
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CST deficiency diminishes RAD51 foci formation and recruitment to fragile sequences