Cryoneurolysis in Patients with Refractory Chronic Peripheral Neuropathic Pain

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• 作者：Jung Hwoon Edward Yoon ; MD^a ; Vadim Grechushkin ; MD^a ; Ammar Chaudhry ; MD^a ; Priya Bhattacharji ; BS^a ; Brian Durkin ; MD^b ; William Moore ; MD^a ; ^{william.moore@stonybrook.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：RF ; radiofrequency
• 刊名：Journal of Vascular and Interventional Radiology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：27
• 期：2
• 页码：239-243
• 全文大小：745 K

文摘

To evaluate the safety and efficacy of cryoneurolysis in patients with refractory peripheral neuropathic pain.

Materials and Methods

Twenty-two patients referred for cryoneurolysis of refractory peripheral neuropathy were recruited prospectively from July 2011 to July 2013. The mean patient age was 49.5 years, and 41% of patients were female. Ultrasound imaging of the involved nerves was used for guidance. Percutaneous ablations were performed with a PerCryo 17R device. Pain levels were recorded on a visual analog scale (scores 0–10) before and at 1, 3, 6, 9, and 12 months after the procedure, and complications were documented.

Results

Mean pain levels were 8.3 ± 1.9 before intervention and 2.3 ± 2.5 at 1 month, 3.2 ± 2.5 at 3 months, 4.7 ± 2.7 at 6 months, and 5.1 ± 3.7 at 12 months afterward. A Wilcoxon rank-sum test was performed and showed a statically significant decrease between pre- and postprocedural pain scores. There were no complications from the procedures.

Discussion

Cryoneurolysis caused a significant decrease in self-reported pain scores in patients with chronic refractory neuropathic pain, with moderately long-term relief. Cryoneurolysis is an additional therapy that can alleviate severe chronic neuropathic pain.