Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

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• 作者：Katherine Y. Peng^a ; ^b ; ^{Katherine.Peng@med.nyu.edu} ; Paul M. Mathews^c ; ^e ; ^{Paul.Mathews@nki.rfmh.org} ; Efrat Levy^b ; ^c ; ^e ; ^{Efrat.Levy@nki.rfmh.org} ; Donald A. Wilson^a ; ^d ; ^f ; ^{Donald.Wilson@nki.rfmh.org}
• 关键词：AD ; Alzheimer&rsquo ; s disease ; ANOVA ; analysis of variance ; ApoE ; apolipoprotein E ; ApoE3 ; apolipoprotein E3 ; ApoE4 ; apolipoprotein E4 ; FFT ; Fast-Fourier transform ; LPF ; local field potentials ; OB ; olfactory bulb ; OERP ; olfactory event-related potential ; PCX ; piriform cortex
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：364-371
• 全文大小：1464 K
• 卷排序：343

文摘

Olfactory deficits are shown in young, but not middle-aged, ApoE4 vs. ApoE3 mice. Young ApoE4 vs. ApoE3 mice exhibit hyperactive LFP response to odors in the OB. Odor-evoked response magnitudes in ApoE4 mice increase in the PCX with age. Spontaneous LFPs in ApoE mice decrease with age in both the OB and the PCX. Spontaneous LFP activity is further reduced in middle-aged ApoE4 vs. ApoE3 mice.