Aberrant tumor-associated antigen autoantibody profiles in healthy controls detected by multiplex bead-based immunoassay

详细信息    查看全文

• 作者：Brian Nolen ; Matt Winans ; Adele Marrangoni ; Anna Lokshin
• 关键词：Tumor-associated antigens ; Autoantibody profiles ; Autoimmunity ; Early detection
• 刊名：Journal of Immunological Methods
• 出版年：2009
• 出版时间：31 May 2009
• 年：2009
• 卷：344
• 期：2
• 页码：116-120
• 全文大小：828 K

文摘

There is an increasing amount of emphasis being placed on serological biomarkers as tools for early detection of various cancers. In addition to the tumor-related circulating antigens under current investigation, autoantibodies to tumor-associated antigens are emerging as alternative candidates due to their potential high sensitivity and specificity. Already a number of specific autoantibodies have been identified and several groups have reported on the ability of panels of autoantibodies to discriminate malignant from non-malignant conditions. In this investigation we evaluate tumor-associated antigen autoantibody profiles in a group of healthy individuals. We identify a subset of individuals that demonstrate high levels of autoantibody production across the spectrum of tumor-associated antigens tested. We conclude that this observation is a result of undefined non-malignant autoimmune stimulation. Our findings may be an indication of factors present in the general population that may confound multiplex autoantibody-based diagnostic tests by reducing assay specificity. Such factors will require further characterization and the development of adequate controls in order to improve the performance of diagnostic tests.