Agouti-related protein-deficient mice display an age-related lean phenotype

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• 作者：Katherine E. Wortley ; Keith D. Anderson ; Jason Yasenchak ; Andrew Murphy ; David Valenzuela ; Sabrina Diano ; George D. Yancopoulos ; Stanley J. Wieg ; ; Mark W. Sleeman
• 关键词：DEVBIO
• 刊名：Cell Metabolism
• 出版年：2005
• 出版时间：December 2005
• 年：2005
• 卷：2
• 期：6
• 页码：421-427
• 全文大小：335 K

文摘

Endogenous modulators of the central melanocortin system, such as the agouti-related protein (AgRP), should hold a pivotal position in the regulation of energy intake and expenditure. Despite this, AgRP-deficient mice were recently reported to exhibit normal food intake, body weight gain, and energy expenditure. Here we demonstrate that 2- to 3-month-old Agrp null mice do in fact exhibit subtle changes in response to feeding challenges (fasting and MCR agonists) but, of more significance and magnitude, exhibit reduced body weight and adiposity after 6 months of age. This age-dependent lean phenotype is correlated with increased metabolic rate, body temperature, and locomotor activity and increased circulating thyroid hormone (T4 and T3) and BAT UCP-1 expression. These results provide further proof of the importance of the AgRP neuronal system in the regulation of energy homeostasis.