A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery
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- 作者：Shihui Yua ; Xiaoyu Zhanga ; Guoxin Tana ; Lei Tiana ; Dandan Liub ; Yaxuan Liua ; Xinggang Yanga ; yangxg123@163.com" class="auth_mail" title="E-mail the corresponding author ; Weisan Pana ; pppwwwsss@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carboxymethyl chitosan ; Poloxamer ; pH-induced thermosensitive hydrogel ; Swelling ; Cytotoxicity
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：208-217
- 全文大小：3030 K
文摘
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A novel pH-induced thermosensitive hydrogel was synthesized.
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Hydrogel had high swelling ratio and sustained release drug.
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Human corneal epithelial cells cytocompatibility demonstrated.
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Potential as ophthalmic drug delivery vehicle.