Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

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• 作者：Chenguang Li^a ; ¹ ; Peizhan Chen^b ; ^c ; ¹ ; Xiaohua Duan^c ; ¹ ; Jing Wang^a ; ¹ ; Bing Shu^a ; Xiaoguang Li^b ; ^c ; Qian Ba^b ; ^c ; Jingquan Li^b ; ^c ; Yongjun Wang^a ; ^d ; ^{yjwang8888@126.com} ; Hui Wang^b ; ^c ; ^e ; ^{huiwang@sibs.ac.cn}
• 关键词：Total 25(OH)D ; Bioavailable 25(OH)D ; Bone mineral density ; Bone turnover biomarkers ; Postmenopausal women
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：184-192
• 全文大小：1099 K
• 卷排序：15

文摘

DBP levels and variants on DBP were associated with the total and bioavailable 25(OH)D levels in the elderly populations. Both the total and bioavailable 25(OH)D levels were correlated with the BMD in postmenopausal women. Multivariate analyses suggested that the bioavailable but not total 25(OH)D was an independent determinant for the BMD. Higher bioavailable 25(OH)D levels were correlated with reduced bone turnover and lower PTH in postmenopausal women.With a cross-sectional community study, we found that the variant rs7041, but not rs4588, of DBP was significantly associated with the blood DBP level, which was positively correlated with the total 25(OH)D levels but negatively associated with the bioavailable 25(OH)D levels. The bioavailable 25(OH)D level was an independent determinant for BMD but not total 25(OH)D. Higher vitamin D levels were correlated with the reduced bone turnover process and lower PTH levels, which might lead to the higher BMD value in postmenopausal women. These results suggested that bioavailable 25(OH)D was a superior biomarker than total 25(OH)D regarding the bone metabolism, and that vitamin D intervention may improve the bone health in elderly populations.