A signal-on electrochemical strategy for protease detection based on the formation of ATCUN-Cu(II)
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- 作者：Ning XiaAuthor Vitae ; Peizhen PengAuthor Vitae ; Shasha WangAuthor Vitae ; Jiaying DuAuthor Vitae ; Gaihong ZhuAuthor Vitae ; Weimin DuAuthor Vitae ; Lin Liu ; liulin@aynu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Electrochemical sensors ; Protease ; ATCUN motif ; Copper ; β-secretase
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：232
- 期：Complete
- 页码：557-563
- 全文大小：1241 K
文摘
We reported a signal-on electrochemical strategy for protease detection.
The method was based on the redox of ATCUN-Cu(II) formed on electrode surface.
The detection limit of this method for β-secretase was 0.08 nmol L−1.
The work would be valuable for fabrication of biosensors based on the metal-binding property of ATCUN.
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