Nanocomposite scaffold with enhanced stability by hydrogen bonds between collagen, polyvinyl pyrrolidone and titanium dioxide
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- 作者：Na Lia ; Xialian Fana ; Keyong Tanga ; kytang@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xuejing Zhenga ; Jie Liua ; Baoshi Wangb
- 关键词：Type I collagen ; Polyvinyl pyrrolidone ; Titanium dioxide ; Nanocomposite scaffold ; Stability
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：287-296
- 全文大小：2821 K
文摘
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Type I collagen with intact triple helical structure from porcine skin was extracted.
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TiO2 nanometer sol was prepared by sol–gel method with distilled water and a little amount of ethanol as reaction medium.
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Nanocomposite scaffold was prepared by freeze drying the mixture of type I collagen and PVP wrapped nano-TiO2 particles, that the procedure was without any cross-linker or toxic reagents to generate porosity.
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Interaction by hydrogen bonds between PVP, TiO2 and collagen was analyzed and discussed.
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Hydrogen-bondings have been found to be the main actor to enhance stability of this ternary nanocomposite.