Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy

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• 作者：Wei-Hai Chen^a ; ¹ ; Guo-Feng Luo^a ; ¹ ; Wen-Xiu Qiu^a ; Qi Lei^a ; Li-Han Liu^a ; Shi-Bo Wang^a ; ^b ; Xian-Zheng Zhang^a ; ^b ; ^{xz-zhang@whu.edu.cn}
• 关键词：Mesoporous silica nanoparticle ; Tumor-target ; Supramolecular photosensitizer ; Dual-modal imaging ; Photodynamic/chemo therapy
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：117
• 期：Complete
• 页码：54-65
• 全文大小：6179 K
• 卷排序：117

文摘

Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd3+) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd3+. The TPZ@MCMSN-Gd3+ could be specifically uptaken by CD44 receptor overexpressed tumor cells and respond to hyaluronidase (HAase) to trigger the release of therapeutics. As confirmed by in vivo studies, TPZ@MCMSN-Gd3+ showed preferential accumulation in tumor site and significantly inhibited the tumor progression by the collaboration of PDT and bioreductive chemotherapy under NIR fluorescence/MR imaging guidance. Taken together, this supraPSs based strategy paves a new paradigm of the way for the construction of theranostic nanoplatform.