Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway
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- 作者：Jialing Wu1 ; Chong Chen1 ; Xi Hu ; Xianbin Cai ; Yinghong Guan ; Hui Hu ; Qinjia Wang ; Xiaofeng Chen ; Bozhi Cai ; Xubin Jing ; xbjing@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX-2 ; Celecoxib ; Nonalcoholic steatohepatitis ; Apoptosis ; Akt ; p53
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：1034-1040
- 全文大小：2197 K
文摘
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Inhibition of COX-2 attenuates NASH in vivo by inhibiting hepatocyte apoptosis.
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We used COX-2 knockout mice to confirm the role of COX-2 in the progression of NASH.
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The mechanism partly relies on the regulation of Akt/p53 signaling pathway.