Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells
详细信息 查看全文
- 作者：Yang Mua ; b ; muyang@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liangliang Lia ; b ; lifeiyang2007@126.com" class="auth_mail" title="E-mail the corresponding author ; Beibei Zhanga ; b ; diana851218@163.com" class="auth_mail" title="E-mail the corresponding author ; Baicheng Huanga ; b ; hbch228@163.com" class="auth_mail" title="E-mail the corresponding author ; Jiming Gaoa ; b ; jimingao2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiangpeng Wanga ; b ; wangxiangpeng2003@126.com" class="auth_mail" title="E-mail the corresponding author ; Chengbao Wanga ; b ; wangchengbao@126.com" class="auth_mail" title="E-mail the corresponding author ; Shuqi Xiaoa ; b ; shqxiaojd@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Qin Zhaoa ; b ; qinzhao_2004@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yani Suna ; b ; yanisun_2005@sina.com" class="auth_mail" title="E-mail the corresponding author ; Gaiping Zhanga ; c ; Zhanggaiping2003@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author ; Julian A. Hiscoxa ; d ; julian.hiscox@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author ; En-Min Zhoua ; b ; zhouem@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PRRSV ; GP5 ; Cell apoptosis ; Virus replication ; IFN
- 刊名：Virology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：484
- 期：Complete
- 页码：136-145
- 全文大小：3362 K
文摘
- •
Marc-145 cell lines stable expression PRRSV GP5 or truncated GP5 were constructed.
- •
GP5螖97-119 expression in Marc-145 cell induced cell cycle arrest at G2/M phase.
- •
Expression of GP5 and truncated GP5 could not induce Marc-145 cells apoptosis.
- •
PRRSV replication in Marc-145-GP5螖84-96 was significantly inhibited.