Detailed profiling on DNA binding affinity, cytotoxicity and pathway of induced cell death of novel water-soluble Cu(Ⅱ)-based acylhydrazone porphyrin derivatives
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- 作者：Xiao-Xia Feng ; Jun-Xiang Zhang ; Yu Wu ; Qian Zhang ; Jia-Cheng Liu ; jcliu8@nwnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cu-based porphyrin complexes ; ct-DNA binding ; Cytotoxicity ; Cellular uptake ; Pathway of cell death
- 刊名：Dyes and Pigments
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：136
- 期：Complete
- 页码：773-781
- 全文大小：1990 K
文摘
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Three novel Cu(Ⅱ)-based acylhydrazone porphyrin derivatives have been synthesized.
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Versatile physicochemical means suggested Cu-Por3 has strongest binding affinity.
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MTT tests showed Cu-Por3 with good cytotoxicity to A549, but weak for normal cell.
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An extraction method was performed to quantified identify the cellular uptake.
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Besides, Cu-Por3 induced A549 death mainly via apoptotic and arrested G1 phase.