UFLC-MS/MS determination and pharmacokinetic studies of six Saikosaponins in rat plasma after oral administration of Bupleurum Dropping Pills
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- 作者：Xiufeng Guana ; b ; 1 ; Xiangyang Wangb ; 1 ; Kaijing Yanb ; Yang Chub ; Shuming Lib ; Wei Lib ; e ; liwei_wzhy@163.com" class="auth_mail" title="E-mail the corresponding author ; Xueying Yana ; yanxueying00@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaohui Mab ; Shuiping Zhoub ; He Sunb ; c ; Changxiao Liud
- 关键词：Saikosaponin ; UFLC&ndash ; MS/MS ; Pharmacokinetics ; Bupleurum dropping pills
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：30 May 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：288-293
- 全文大小：1246 K
文摘
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UFLC–ESI–MS/MS utilized for PK study of six Saikosaponins following oral administration of Bupleurum Dropping Pills.
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The assay simultaneously determines six Saikosaponins components in rat plasma.
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LLOQs of these six active components are 0.2 ng/ml.
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This is the first pharmacokinetic study of multiple active constituent absorbed into plasma after oral administration of Bupleurum Dropping Pills in rats.