- 作者：Hima B. Tam Tam ; Oonagh Dowling ; Xiangying Xue ; Dawnette Lewis ; Burton Rochelson ; Christine N. Metz
- 关键词：chemokines ; cytokines ; fetal brain damage ; GRO-KC ; magnesium sulfate ; maternal infection ; MCP-1
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2011
- 出版时间：April 2011
- 年：2011
- 卷：204
- 期：4
- 页码：364.e1-364.e8
- 全文大小：1401 K
Objective
Magnesium sulfate is proposed to have neuroprotective effects in the offspring. We examined the effects of maternal magnesium sulfate administration on maternal and fetal inflammatory responses in a rat model of maternal infection.Study Design
Pregnant rats were injected with saline, Gram-negative bacterial endotoxin lipopolysaccharide or lipopolysaccharide with magnesium sulfate (pre- and/or after lipopolysaccharide) to mimic infection. Maternal blood, amniotic fluid, fetal blood, and fetal brains were collected 4 hours after lipopolysaccharide and assayed for tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC. In addition, the effect of magnesium sulfate on cytokine production by an astrocytoma cell line was assessed.
Results
Lipopolysaccharide administration induced tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC expression in maternal and fetal compartments. Maternal magnesium sulfate treatment significantly attenuated lipopolysaccharide-induced multiple proinflammatory mediator levels in maternal and fetal compartments.
Conclusion
Antenatal magnesium sulfate administration significantly ameliorated maternal, fetal, and gestational tissue-associated inflammatory responses in an experimental model of maternal infection.