Smad4 is required for the development of cardiac and skeletal muscle in zebrafish
详细信息 查看全文
- 作者：Jie Yang1 ; yangjie@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Junnai Wang1 ; 865646064@qq.com" class="auth_mail" title="E-mail the corresponding author ; Zhen Zeng 304527694@qq.com" class="auth_mail" title="E-mail the corresponding author ; Long Qiao 498801939@qq.com" class="auth_mail" title="E-mail the corresponding author ; Liang Zhuang mrzhuangliang@126.com" class="auth_mail" title="E-mail the corresponding author ; Lijun Jiang 278308418@qq.com" class="auth_mail" title="E-mail the corresponding author ; Juncheng Wei 191320607@qq.com" class="auth_mail" title="E-mail the corresponding author ; Quanfu Ma 99213704@qq.com" class="auth_mail" title="E-mail the corresponding author ; Mingfu Wu wumingfuwh@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Shuangmei Ye 29011378@qq.com" class="auth_mail" title="E-mail the corresponding author ; Qinglei Gao 2482880446@qq.com" class="auth_mail" title="E-mail the corresponding author ; Ding Ma dma@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoyuan Huang ; huangxy@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：smad4 ; SMAD family member 4 ; vmhc ; ventricular myosin heavy chain ; amhc ; myh6 myosin ; heavy chain 6 ; cardiac muscle ; alpha ; cmlc2 ; myl7 ; myosin ; light chain 7 ; regulatory
- 刊名：Differentiation
- 出版年：2016
- 出版时间：October-November 2016
- 年：2016
- 卷：92
- 期：4
- 页码：161-168
- 全文大小：2111 K
文摘
- •
Smad4 was expressed at all developmental stages of zebrafish.
- •
Knockdown of smad4 in embryos resulted in defects in the heart and the trunk structure.
- •
Knockdown of smad4 in embryos downregulated the expression of two heart-chamber markers.
- •
Knockdown of smad4 in embryos increased the expression of myogenic regulatory factors.
- •
Knockdown of smad4 in embryos resulted in an obvious increase of cell apoptosis.