Increased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4
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- 作者：Xiaobin Fenga ; 1 ; Lifen Zhaoa ; 1 ; Shuhang Gaob ; Xiaobo Songc ; Weijie Dongd ; Yongfu Zhaoe ; Huimin Zhouf ; Lei Chengg ; Xiaolong Miaoe ; Li Jiaa ; jiali0386@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MDR ; multidrug resistance ; FUTs ; fucosyltransferases ; miRNAs ; microRNAs ; 3&prime ; -UTRs ; 3&prime ; -untranslated regions ; GDP-Fuc ; guanosine diphosphate β-l-fucose ; 5-Fu ; fluorouracil ; PNGaseF ; enzyme peptide ; N-glycosidase F enzyme ; HLB ; hydrophilic-lipophilic balance ; PBS ; phosphate buffered saline ; Tween 20 ; polyoxyethylene sorbitan monolaurate ; PBST ; phosphate buffered ; saline with Tween-20 ; MALDI-TOF ; matrix-assisted laser desorption ionization-time of flight ; MS ; mass spectrometric ; ADR ; adria
- 刊名：Gene
- 出版年：2016
- 出版时间：10 March 2016
- 年：2016
- 卷：578
- 期：2
- 页码：232-241
- 全文大小：1171 K
文摘
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Fucosylation was identified to be associated with MDR in breast cancer cells.
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Fucosyltransferases may contribute to the prognosis of breast cancer.
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miR-224-3p can mediate MDR in breast cells through targeting FUT4.
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miR-224-3p/FUT4 may serve as therapeutic targets to reverse chemoresistance.
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