DNA microarray-mediated transcriptional profiling of avian pathogenic Escherichia coli O2 strain E058 during its infection of chicken
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- 作者：Qingqing Gao gq00888@sina.com" class="auth_mail" title="E-mail the corresponding author ; Le Xia 1406480277@qq.com" class="auth_mail" title="E-mail the corresponding author ; Juanhua Liu 1473668159@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xiaobo Wang wangxb@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Song Gao ; gsong@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiufan Liu xfliu@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian pathogenic Escherichia coli ; Microarray ; Genome-wide expression ; In vivo
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：1-9
- 全文大小：490 K
文摘
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In vivo transcriptional response of APEC E058 bacteria collected from the blood of infected chickens was identified.
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The genes highly expressed involved in metabolism, iron acquisition, virulence, stress response, and so on.
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The reliability of the microarray data was confirmed by performing quantitative real-time PCR on 12 representative genes.
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Several significantly upregulated genes were selected to study their role in APEC pathogenesis.
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The data will help to better understand the mechanisms of APEC pathogenesis.