Amyloid-graphene oxide as immobilization platform of Au nanocatalysts and enzymes for improved glucose-sensing activity

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• 作者：Xiaochen Wu^a ; Mingjie Li^a ; Zehui Li^b ; Lili Lv^a ; Yan Zhang^c ; Chaoxu Li^a ; ^{licx@qibebt.ac.cn}
• 关键词：Amyloid nanofibrils ; Graphene oxide ; Au nanoparticles ; Biocompatible immobilization platform ; Biosensing
• 刊名：Journal of Colloid and Interface Science
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：490
• 期：Complete
• 页码：336-342
• 全文大小：2344 K
• 卷排序：490

文摘

Two-dimensional GO nanosheets and one-dimensional lysozyme nanofibrils were hybridized through electrostatic interaction to get a novel amyloid-GO composite, which promised a biocompatible immobilization platform for Au nanocatalysts as well as enzymes. The immobilization platform could load a large and tunable amount of Au NPs while maintaining their high catalytic activity. The immobilized catalysts showed high electrochemical behaviors, being ideal as glucose sensing systems. Furthermore, enzymes could also be immobilized on the residual bare surfaces of amyloid-GO, and served by a colorimetric method for a sensitive and selective analytical glucose-detecting platform. The introduction of amyloid fibrils with super large aspect ratios (>103) on GO nanosheets offers an unprecedented possibility of designing and developing novel biomimetic catalysts for broad applications in biotechnology.