Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation
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- 作者：Yimeng Zhang ; Youwei Xu ; Yan Qi ; Lina Xu ; Shasha Song ; Lianhong Yin ; Xufeng Tao ; Yuhong Zhen ; Xu Han ; Xiaodong Ma ; Kexin Liu ; Jinyong Peng ; jinyongpeng2014@163.com ; jinyongpeng2005@163.com
- 关键词：Dox ; doxorubicin ; FXR ; the farnesoid X receptor ; AMPKα ; AMP- activated protein kinase α ; HO-1 ; hemeoxygenase-1 ; GST ; glutathione-s-transferase ; Nrf2 ; NF-E2-related factor 2 ; BUN ; blood urea nitrogen ; Cr ; creatinine ; HMGB1 ; high mobility group box 1 ; NF-κB ; nuclear factor kappa B ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; TNF-α ; tumor necrosis factor alpha ; siRNA ; small interfering RNA ; H12 ; helix12
- 刊名：Toxicology
- 出版年：2017
- 出版时间：1 March 2017
- 年：2017
- 卷：378
- 期：Complete
- 页码：53-64
- 全文大小：6769 K
- 卷排序：378
文摘
Dioscin significantly protected doxorubicin-induced cell injury. Dioscin protected doxorubicin-induced nephrotoxicity in rats. Dioscin significantly suppressed oxidative stress and inflammation. Dioscin adjusted FXR-mediated signal pathway in vitro and vivo. Dioscin directly targeted with FXR.