Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway
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- 作者：Xi Yang1 ; Genhong Yao1 ; Weiwei Chen ; Xiaojun Tang ; Xuebing Feng ; Lingyun Sun ; lingyunsun@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lupus nephritis ; High salt diet ; Serum and glucocorticoid-inducible serine/threonine protein kinase 1
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：568-573
- 全文大小：996 K
文摘
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High salt diet deteriorated the disease severity of lupus.
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High salt diet affected the Th1/Th2 and Th17/Treg balance in vivo.
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High salt shifted balance of Th17/Treg towards Th17 in vitro.
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Serum and glucocorticoid-inducible serine/threonine protein kinase 1(SGK1) inhibitor abolished the effect of high salt on CD4 + T cells in vitro.