Staurosporine as an agonist for induction of GLUT4 translocation, identified by a pH-sensitive fluorescent IRAP-mOrange2 probe
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- 作者：Yufeng Lia ; b ; 1 ; Li Zhengb ; 1 ; Dan Wangb ; 1 ; Xiang Zhangb ; Jia Lic ; Sher Alib ; Jingze Lub ; Hao Zonga ; zonghaocsd@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaolan Xub ; xiaolanxu@moon.ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetes ; pH-sensitive fluorescent probe ; GLUT4 translocation ; Staurosporine ; Insulin additive analogue
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：534-538
- 全文大小：590 K
文摘
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Staurosporine was identified and validated as an insulin additive analogue.
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Staurosporine promotes GSVs translocation and glucose uptake through the AMPK pathway.
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A novel probe IRAP-mOrange2 was applied to monitor the translocation of GSVs.