Development and validation of a UFLC-MS/MS method for determination of 7′(Z)-(8″pan style='font-style: italic'>S, 8‴pan style='font-style: italic'>S)-epi-salvianolic acid E, (7′R, 8′pan style='font-style: italic'>R, 8″pan style='font-style: italic'>S, 8‴pan style='font-style: italic'>S)-epi-salvianolic acid B and salvianolic acid B in rat
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- 作者：Xiuman Xiea ; 1 ; Wanyang Suna ; 1 ; Jingzhuo Miaoa ; Jingyi Huangb ; Jingyao Xub ; Xiaolin Liub ; Henry Sunb ; Ling Tongb ; tongling@tasly.com" class="auth_mail" title="E-mail the corresponding author ; Guoxiang Suna ; gxswmwys@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：7&prime ; (Z)-(8&Prime ; S ; 8‴S)-epi-Salvianolic acid E ; (7&prime ; R ; 8&prime ; R ; 8&Prime ; S ; 8‴S)-epi-Salvianolic acid B ; Salvianolic acid B ; UFLC-MS/MS ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1022
- 期：Complete
- 页码：6-12
- 全文大小：987 K
文摘
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Determination of two novel analogs of salvianolic acid B in rat plasma by UFLC-MS/MS.
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Only 3.0 min was in need for one analytical run.
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Application to the study of pharmacokinetic behaviors of the two novel compounds.
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This study benefits further researches in the process of drug development.