Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis

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• 作者：Junchao Xue^a ; ^b ; ¹ ; Yang Liu^c ; ¹ ; Fei Luo^a ; ^b ; Xiaolin Lu^a ; ^b ; Hui Xu^a ; ^b ; Xinlu Liu^a ; ^b ; Lu Lu^a ; ^b ; Qianlei Yang^a ; ^b ; Chao Chen^a ; ^b ; Weimin Fan^c ; Qizhan Liu^a ; ^b ; ^{drqzliu@hotmail.com}
• 关键词：circRNAs ; miRNAs ; Cell cycle ; Carcinogenesis ; Arsenite
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：753-763
• 全文大小：2383 K
• 卷排序：1863

文摘

Arsenite induces the up-regulation of circ100284, which regulates the cell cycle in arsenite carcinogenesis. miR-217, via EZH2, is involved in increases of cyclin D1. circ100284, via miR-217 regulation of EZH2, is involved in the accelerated cell cycle in arsenite carcinogenesis.