Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis
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- 作者：Yongping Zhang1 ; 2 ; Xiaoman Liu1 ; 2 ; Jian Bai1 ; 2 ; 3 ; Xuejun Tian1 ; Xiaocui Zhao1 ; Wei Liu1 ; Xiuying Duan1 ; Weina Shang1 ; Heng-Yu Fan1 ; Chao Tong1 ; ctong@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：neurodegeneration ; mitochondrial fusion ; MitoPLD ; Drosophila
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 January 2016
- 年：2016
- 卷：61
- 期：1
- 页码：111-124
- 全文大小：7713 K
文摘
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The miga mutant maintains neuronal homeostasis in fly photoreceptor cells
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MIGA1/2 are mitochondrial outer membrane proteins regulating mitochondrial fusion
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MIGA1/2 function occurs downstream of the mitofusin proteins
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MIGA1/2 regulate mitochondrial fusion through MitoPLD