A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

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• 作者：Zongxi Han ; Chuyang Sun ; Baolong Yan ; Xiaonan Zhang ; Yu Wang ; Chengren Li ; Qingxia Zhang ; Yazhen Ma ; Yuhao Shao ; Qiaoran Liu ; Xiangang Kong ; Shengwang Liu
• 关键词：Molecular epidemiology ; Avian infectious bronchitis coronavirus ; Genotype
• 刊名：Infection, Genetics and Evolution
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：11
• 期：1
• 页码：190-200
• 全文大小：532 K

文摘

A comprehensive study of the epidemiology and pathogenicity of infectious bronchitis virus (IBV) in China was carried out by molecular characterization of the S1 gene from 46 isolates obtained for this study and 174 reference strains isolated over a 15-year period. Nine types were found according to sequence analysis and phylogenetic study of the S1 gene. The co-circulation of multiple IBV types and the ongoing emergence of IBV variants are the epidemiological challenges in China. Factors contributing to the continual emergence include mutations, insertions and deletions in the S1 protein genes; recombination between local IBV strains circulating in chicken flocks in China; and recombination between local strains and vaccine strains. Vaccination-challenge analysis between circulating field strains and Mass-type H120 vaccine indicated the need to develop new vaccines from local IBV strains. These results also emphasize the importance of continued IBV surveillance in China.