Identification of a diverse synthetic abietane diterpenoid library for anticancer activity

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• 作者：Hongtao Xu^a ; ^b ; ¹ ; Lili Liu^a ; ¹ ; Xiaoting Fan^a ; ^d ; ¹ ; Guanjun Zhang^c ; Yuanchao Li^b ; Biao Jiang^a ; ^{jiangbiao@shanghaitech.edu.cn}
• 关键词：Abietic acid ; Triptophenolide ; Diverse ; Natural-product-like ; Anticancer
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：27
• 期：3
• 页码：505-510
• 全文大小：1097 K
• 卷排序：27

文摘

A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay.