Contribution of carboxyl modified chiral mesoporous silica nanoparticles in delivering doxorubicin hydrochloride in vitro: pH-response controlled release, enhanced drug cellular uptake and cytotoxicity
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- 作者：Jing Lia ; Xiaotong Dub ; Nan Zhenga ; Lu Xua ; Jinghua Xub ; jinghuaxu2002@tom.com" class="auth_mail" title="E-mail the corresponding author ; Sanming Lia ; li_sanming2013@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chiral mesoporous silica nanoparticles ; Carboxyl modification ; pH-response ; Doxorubicin hydrochloride
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：374-381
- 全文大小：2662 K
文摘
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Dual functionalized mesoporous silica nanoparticle (Dual-MSN) was developed.
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Dual-MSN exhibited enhanced pH-response due to negative charges of carboxyl group.
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Dual-MSN had unique advantages in improving cytotoxicity towards MCF-7 cells.