Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents

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• 作者：Xiaotong Cui^a ; ¹ ; ² ; Jingmin Zhou^a ; ¹ ; ² ; Xuejuan Jin^a ; ¹ ; ² ; Jun Zhou^a ; ¹ ; Michael Fu^b ; ³ ; Kai Hu^a ; ¹ ; Aijun Sun^a ; ¹ ; Junbo Ge^a ; ¹ ; ^{jbge@zs-hospital.sh.cn}
• 关键词：Diastolic dysfunction ; Heart failure ; Preserved ejection fraction ; Epidemiology ; Elderly
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：820-825
• 全文大小：351 K
• 卷排序：227

文摘

Left ventricular diastolic dysfunction (LVDD) is closely related to heart failure with preserved ejection fraction (HFpEF), while the prevalence and correlates of either LVDD or HFpEF in elderly population remain largely unknown.MethodsThe study was performed in 1274 community residents (769 women, aged ≥ 65 years) who participated in the Shanghai Heart Health Study. Demographic, laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis.ResultsLVDD was detected in 31.9% (406/1274) residents and it was significantly higher in women than in men (34.2% vs. 28.3%, P = 0.027). HFpEF prevalence was 2.8% (35/1274), and increased with aging in the whole cohort. For residents with left ventricular ejection fraction ≥ 50% and normal-sized ventricular cavity, female sex (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.24–2.29), heart rate (OR 0.76, 95% CI 0.68–0.86), atrial fibrillation (OR 7.37, 95% CI 3.13–17.36), hypertension (OR 1.32, 95% CI 1.00–1.75), N-terminal pro-B type natriuretic peptide (OR 2.33, 95% CI 1.50–3.61) and high-sensitivity troponin T (hs-TnT) (OR 1.90, 95% CI 1.12–3.23) were independent correlates of asymptomatic LVDD. While age (OR 1.44, 95% CI 1.01–2.06), heart rate (OR 0.66, 95% CI 0.47–0.93) and hs-TnT (OR 4.37, 95% CI 1.46–13.12) were independently related to HFpEF.ConclusionsLVDD is common in this community elderly population, and HFpEF is also not rare. Different factors played roles in different stages of HFpEF. Future studies are warranted to explore the predictors of LVDD and HFpEF in the community elderly.