Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn

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• 作者：Ying Peng^c ; Li-Li Lou^a ; ^b ; Si-Fan Liu^a ; ^b ; Le Zhou^a ; ^b ; Xiao-Xiao Huang^a ; ^b ; ^{xiaoxiao270@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shao-Jiang Song^a ; ^b ; ^{songsj99@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Hawthorn ; Crataegus pinnatifida ; Seeds ; Neolignan ; Antioxidant ; Anti-inflammatory
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：26
• 期：22
• 页码：5501-5506
• 全文大小：439 K

文摘

Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7–12 exhibited marked nitric oxide (NO) inhibition and compounds 1–4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.