Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation

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• 作者：Chang Gao^a ; ^b ; Di Wang^a ; ^b ; Yan Zhang^c ; Xiao-Xiao Huang^a ; ^b ; ^{xiaoxiao270@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shao-Jiang Song^a ; ^b ; ^{songsj99@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diterpenoids ; Tripterygium wilfordii ; Cytotoxicity ; Celastraceae ; Ent-kaurane ; Aromatic abietane
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 June 2016
• 年：2016
• 卷：26
• 期：12
• 页码：2942-2946
• 全文大小：568 K

文摘

Kaurane diterpenoids and abietane diterpenoids are the major anti-tumor components in Tripterygium wilfordii (Celastraceae). Extraction of Tripterygium wilfordii afforded a new diterpenoid and twenty known diterpenoids belonging to the abietane and ent-kaurane families. The structures of all these compounds were characterized by spectroscopic techniques. All compounds were evaluated using the MTT method for in vitro cytotoxicity against six human cancer cell lines (HepG2, Hep3B, Bcap37, U251, MCF-7 and A549). Compounds 7 and 12 exhibited marked cytotoxicity against a six cell lines with IC₅₀ values in the range 5.10–23.30 μM. The structure–cytotoxic activity relationships of these diterpenoids are also discussed.