Accompanying mild hypothermia significantly improved the prognosis of septic mice than artificial mild hypothermia

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• 作者：Xiao-shuang Li ; MS ^{lxsmm1206@163.com" class="auth_mail" title="E-mail the corresponding author} ; Li Liu ; MS ; Yu-lian Jin ; MD ; Fei-fei Luo ; MS ; Lin Li ; MS ; Jingfeng Zhu ; MD ; Qilian Xie ; MD ; ^{xieqilian123@163.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：The American Journal of Emergency Medicine
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：33
• 期：11
• 页码：1651-1658
• 全文大小：1294 K

文摘

Some patients with sepsis are found with accompanying mild hypothermia (ACMH); however, the effects of ACMH on the patients with sepsis are poorly understood.

Objective

To compare the impacts of ACMH and artificial mild hypothermia (ATMH) on mortality, systemic inflammatory reactions, and organ functions in mice with sepsis.

Methods

Septic mouse models were induced and divided into ACMH, un-hypothermia, keep normothermia, and ATMH groups, according to the anal temperature and the thermic intervention strategy. The mortality rate, serum levels of tumor necrosis factor 伪 (TNF-伪), interferon 纬 (IFN-纬), and interleukin (IL)-4 and liver and renal functions of the mice in each group were recorded. Liver, lung, and renal tissues of the mice were stained and examined under optic microscope.

Results

The mortality rate in the ACMH group was the lowest among all the sepsis groups. Increased serum levels of TNF-伪, IFN-纬, and IL-4 and impairments of the liver and renal functions were found in the septic mice. The serum levels of TNF-伪, IFN-纬, and IL-4 were significantly lower and the liver and renal functions of ACMH group were not impaired significantly as compared with other sepsis groups. Pathological examinations of the lung, liver, and renal tissues showed that the ACMH group were with the lowest pathological score among all the sepsis groups.

Conclusion

Accompanying mild hypothermia and ATMH could both reduce mortalities in mice with sepsis, and ACMH could reduce mortality even lower, and more alleviate systemic inflammatory responses and the damages in lung, kidney, and other organs were lighter.