Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats
详细信息 查看全文
- 作者：Yan-Fei Mao ; Xing-Feng Zheng ; Jian-Mei Cai ; Xin-Min You ; Xiao-Ming Deng ; John H. Zhang ; Lai Jiang ; Xue-Jun Sun
- 关键词：Intestinal ischemia/reperfusion ; Oxidative stress ; Lung injury ; Antioxidant ; Hydrogen-rich saline
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2009
- 出版时间：17 April 2009
- 年：2009
- 卷：381
- 期：4
- 页码：602-605
- 全文大小：259 K
文摘
Objective. Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. Methods. Male Sprague–Dawley rats (n = 30, 200–220 g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5 ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5 ml/kg, i.v.) groups. Intestinal I/R was produced by 90 min of intestinal ischemia followed by a 4 h of reperfusion. Results. Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-κB activation and the pro-inflammatory cytokine interleukin IL-1β and TNF-α in the lung tissues compared with those in saline-treated rat. Conclusion. Hydrogen-rich saline attenuates lung injury induced by intestinal I/R.