Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex
详细信息 查看全文
- 作者：Bo Xing ; Yan-Chun Li ; Wen-Jun Gao ; wgao@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AC ; adenylate cyclase ; ADHD ; attention deficit hyperactivity disorder ; Akt ; protein kinase B ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; cAMP ; Cyclic adenosine monophosphate ; DA ; dopamine ; DAG ; diacylglycerol ; DAT ; dopamine transporter ; DARPP-32 ; dopamine- and cAMP-regulated phosphoprotein ; Mr 32 ; kDa ; EPSC ; excitatory postsynaptic current ; EPSP ; excitatory postsynaptic potential ; FS ; fast-spiking ; GABA ; gamma-aminobutyric acid ; GSK-3 ; glycogen synthase kinase-3 ; IP3 ; inosit
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：1641
- 期：part_PB
- 页码：217-233
- 全文大小：1192 K
文摘
- •
The role NE and DA play in regulation of prefrontal synaptic function.
- •
NE and DA are essential for PFC functioning.
- •
NE and DA modulation of synaptic transmission in the PFC circuitry.
- •
Akt/GSk-3β signaling as a novel integrator of NE and DA interaction?
- •
Perspectives and critical topics for future studies.