Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract
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- 作者：Yi Liua ; b ; 1 ; Bairu Wanga ; b ; 1 ; Xinlu Liua ; b ; 1 ; Lu Lua ; b ; Fei Luoa ; b ; Xiaolin Lua ; b ; Le Shia ; b ; Wenchao Xua ; b ; Qizhan Liua ; b ; drqzliu@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; drqzliu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：lncRNAs ; Cell cycle ; Epigenetic silencing ; Cigarette smoke extract (CSE) ; Carcinogenesis
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：240
- 期：1
- 页码：60-67
- 全文大小：1883 K
文摘
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CSE enhances transfer of H3K27me3 to the p21 promoter via HOTAIR in HBE cells.
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CSE accelerates the G1/S transition by inhibiting p21 expression in HBE cells.
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Epigenetic silencing of p21 by HOTAIR is involved in CSE-induced cell cycle disorder.