Annexin A2 inhibits the migration of PASMCs stimulated with HPS rat serum by down-regulating the expression of paxillin
详细信息 查看全文
- 作者：Yang Chen1 ; Xinrong Wen1 ; Zhi Wang ; Jing Zeng ; Bin Chen ; Yong Yang ; Kaizhi Lu ; Jianteng Gu ; gjt1976@163.com" class="auth_mail" title="E-mail the corresponding author ; Bin Yi ; yibin1974@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatopulmonary syndrome ; Pulmonary artery smooth muscle cells ; ANXA2 ; Paxillin ; Migration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：469
- 期：1
- 页码：70-75
- 全文大小：997 K
文摘
- •
Annexin A2 (ANXA2) plays regulatory role in Hepatopulmonary syndrome (HPS) associated pulmonary vascular remodelling (PVR).
- •
HPS rat serum increased the migration of pulmonary artery smooth muscle cells (PASMCs) and expression of ANXA2.
- •
After silencing ANXA2 with siRNA, HPS serum-induced up-regulation of paxillin expression was reversed.
- •
Down-regulation of ANXA2 significantly inhibited the migration of PASMCs.