Dynamic activation of basilar membrane macrophages in response to chronic sensory cell degeneration in aging mouse cochleae

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• 作者：Mitchell D. Frye ^{mfrye@buffalo.edu} ; Weiping Yang¹ ; ^{yangwp301@126.com} ; Celia Zhang ^{celiazha@buffalo.edu} ; Binbin Xiong ^{xiongbb2015@126.com} ; Bo Hua Hu ; ^{bhu@buffalo.edu}
• 关键词：Macrophage ; Hair cells ; C57BL/6J ; Cochlea ; Aging ; Immunity
• 刊名：Hearing Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：344
• 期：Complete
• 页码：125-134
• 全文大小：2623 K
• 卷排序：344

文摘

Chronic cochlear degeneration activates basilar membrane macrophages. The activation pattern is affected by the phases of hair cell pathogenesis. Macrophage activation precedes sensory cell pathogenesis. Apical versus basal macrophages exhibit different immune response patterns. Mature tissue macrophages are an immune sensor for chronic hair cell degeneration.