Association between polymorphisms of the HSPB7 gene and Cheyne-Stokes respiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure

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• 作者：Mengmei Wang¹ ; ^{rainman@Yeah.net" class="auth_mail" title="E-mail the corresponding author} ; Hao Ding¹ ; ^{18052885715@189.cn" class="auth_mail" title="E-mail the corresponding author} ; Jing Kang ^{kangjing429@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ke Hu ; ^{huke-rmhospital@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{hukejx@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wen Lu ^{xxxxxx11031103@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiufang Zhou ^{769636185@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Lifang Xu ^{573360964@qq.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cheyne&ndash ; Stokes respiration with central sleep apnea (CSR-CSA) ; Congestive heart failure (CHF) ; Dilated cardiomyopathy (DCM) ; HSPB7 ; Polymorphism ; Gene
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：926-931
• 全文大小：531 K

文摘

CSR-CSA is frequent in patients with CHF. Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background, yet one of the leading etiological causes of CHF. Studies have showed that the HSPB7 gene is associated with DCM.

Objectives

We aimed to explore the prevalence of polymorphisms of the HSPB7 gene in the Chinese Han population with CSR-CSA and CHF caused by DCM.

Methods

A total of 503 unrelated subjects of the Chinese Han population, including 283 CHF patients caused by DCM and 220 healthy controls, were involved in the study. The CHF patients were classified as the CSA-CHF group and the non-CSA-CHF group according to the PSG parameters. The rs1739843 polymorphisms of the HSPB7 gene were identified by real-time quantitative polymerase chain reaction.

Results

In the present study, 35.8% of CHF patients caused by DCM had CSR-CSA. Comparison demonstrated that the CSA-CHF group had significantly higher TT genotype and T allele frequencies in the rs1739843 single nucleotide polymorphism (SNP) of the HSPB7 gene. There were no significant differences among the CC genotype distribution of the CSA-CHF group and the non-CSA-CHF group or the control group.

Conclusions

The rs1739843 polymorphism of the HSPB7 gene might be involved in the pathogenesis of CSR-CSA and CHF subjects caused by DCM in the Chinese Han population. This finding was from a genetic search for the role of the HSPB7 gene in CSR-CSA of CHF patients caused by DCM.