Metabolomics and its application to the evaluation of the efficacy and toxicity of traditional Chinese herb medicines
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- 作者：Jian Shia ; b ; Bei Caoa ; b ; Xin-Wen Wanga ; Ji-Ye Aaa ; c ; jiyea@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; jiye_2005@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Jin-Ao Duand ; Xuan-Xuan Zhud ; Guang-Ji Wanga ; Chang-Xiao Liue
- 关键词：COMET ; Consortium for Metabonomic Toxicology ; GC&ndash ; MS ; gas chromatography&ndash ; mass spectrometry ; HPLC/DAD/ESI&ndash ; MS ; high performance liquid chromatography/diode-array detection/electrospray ionization&ndash ; mass spectrometry ; HPLC-MS ; high performance liquid chromatography mass spectrometry ; NMR ; nuclear magnetic resonance ; PCA ; principal component analysis ; PLS-DA ; partial least squares discriminate analysis ; SD ; Sprague-Dawley ; TCA ; tricarboxylic acid ; TCHMs ; Traditional Chinese herb
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：204-216
- 全文大小：2273 K
文摘
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The multiple components and targets make evaluation of TCHMs very challenging.
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Metabolomics offers novel and potential opportunities to reinvestigate TCM.
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We review current progress of metabolomics assessing TCHMs efficacy and toxicity.