Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy

详细信息    查看全文

• 作者：Wei-Hai Chen^a ; ¹ ; Guo-Feng Luo^a ; ¹ ; Qi Lei^a ; Feng-Yi Cao^a ; Jin-Xuan Fan^a ; Wen-Xiu Qiu^a ; Hui-Zhen Jia^a ; Sheng Hong^a ; Fang Fang^b ; Xuan Zeng^a ; Ren-Xi Zhuo^a ; Xian-Zheng Zhang^a ; ^{xz-zhang@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mesoporous silica nanoparticle ; Tumor-targeted ; Magnetic resonance imaging ; Theranostic ; Precise therapy
• 刊名：Biomaterials
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：76
• 期：Complete
• 页码：87-101
• 全文大小：5166 K

文摘

In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper β-cyclodextrin (β-CD) was immobilized on the surface of mesoporous silica shell via platinum(IV) prodrug linking for reduction-triggered intracellular drug release. Then Arg-Gly-Asp (RGD) peptide ligand was further introduced onto the gatekeeper β-CD via host–guest interaction for cancer targeting purpose. After active-targeting endocytosis by cancer cells, platinum(IV) prodrug in MMSNs would be restored to active platinum(II) drug in response to the innative reducing microenvironment in cancer cells, resulting in the detachment of β-CD gatekeeper and thus simultaneously triggering the in situ release of anticancer drug doxorubicin (DOX) entrapped in the MMSNs to kill cancer cells. It was found that with the aid of an external magnetic field, drug loaded MMSNs showed high contrast in MR imaging in vivo and exhibited magnetically enhanced accumulation in the cancer site, leading to significant inhibition of cancer growth with minimal side effects. This multifunctional MMSN will find great potential as a theranostic nanoplatform for cancer treatment.