EZH2, an on-off valve in signal network of tumor cells
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- 作者：Shanshan Suna ; Feng Yub ; Lun Zhanga ; lunzhangchina@163.com" class="auth_mail" title="E-mail the corresponding author ; Xuan Zhoua ; byron2000zhou@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EZH2 ; Double facet ; Signaling ; Histone modulation ; Tumor
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：481-487
- 全文大小：869 K
文摘
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EZH2 mediates downstream targets transcriptional activation or repression in a context-specific dependent manner.
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EZH2 acts as both an epigenetic gatekeeper and a Defender in tumors.
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EZH2 confronts with miRNAs upon gene silencing.
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Phosphorylation of EZH2—separate sites, separate effects