Enhanced apatite-forming ability and cytocompatibility of porous and nanostructured TiO₂/CaSiO₃ coating on titanium

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• 作者：Hongjie Hu ; Yuqin Qiao ; Fanhao Meng ; Xuanyong Liu ; ^{xyliu@mail.sic.ac.cn} ; Chuanxian Ding
• 关键词：TiO2 ; CaSiO3 ; Coating ; Apatite ; Cytocompatibility
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2013
• 出版时间：1 January, 2013
• 年：2013
• 卷：101
• 期：Complete
• 页码：83-90
• 全文大小：1544 K

文摘

To improve the bioactivity and cytocompatibility of biomedical titanium dioxide coating, many efforts have been made to modify its surface composition and topography. Meanwhile, CaSiO₃ was commonly investigated as coating material on titanium implants for fast fixation and firm implant-bone attachment due to its demonstrated bioactivity and osteointegration. In this work, gradient TiO₂/CaSiO₃ coating on titanium was prepared by a two-step procedure, in which porous and nanostructured TiO₂ coating on titanium was prepared by plasma electrolytic oxidation in advance, and then needle and flake-like CaSiO₃ nanocrystals were deposited on the TiO₂ coating surface by electron beam evaporation. In view of the potential clinical applications, apatite-forming ability of the TiO₂/CaSiO₃ coating was evaluated by simulated body fluid (SBF) immersion tests, and MG63 cells were cultured on the surface of the coating to investigate its cytocompatibility. The results show that deposition of CaSiO₃ significantly enhanced the apatite-forming ability of nanostructured TiO₂ coating in SBF. Meanwhile, the MG63 cells on TiO₂/CaSiO₃ coating show higher proliferation rate and vitality than that on TiO₂ coating. In conclusion, the porous and nanostructured TiO₂/CaSiO₃ coating on titanium substrate with good apatite-forming ability and cytocompatibility is a potential candidate for bone tissue engineering and implant coating.