Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells
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- 作者：Liankai Chi1 ; 6 ; Beibei Fan1 ; 6 ; Kunshan Zhang2 ; Yanhua Du3 ; Zhongliang Liu1 ; Yujiang Fang1 ; Zhenyu Chen1 ; Xudong Ren1 ; Xiangjie Xu1 ; Cizhong Jiang3 ; Siguang Li2 ; Lin Ma1 ; 4 ; Liang Gao1 ; lianggaoh@126.com" class="auth_mail" title="E-mail the corresponding author ; Ling Liu1 ; 4 ; lliu@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoqing Zhang1 ; 2 ; 4 ; 5 ; xqzhang@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：medial ganglionic eminence ; floor plate ; neural specification ; human pluripotent stem cell ; regenerative medicine
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：7
- 期：5
- 页码：941-954
- 全文大小：6843 K
文摘
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EB and AD paradigms yield different ventral neuroprogenitors upon SHH patterning
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DA neurons of FP origin are generated in AD conditions upon SHH patterning
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Wnts/STAT3/p38 inhibition benefits MGE specification under AD conditions
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GABA and CHAT neurons of MGE origin are generated in EB or AD/3i conditions