The production mechanism and immunosuppression effect of pulmonary surfactant protein D via toll like receptor 4 signaling pathway in human corneal epithelial cells during Aspergillus fumigatus infection
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- 作者：Xian Wu ; Guiqiu Zhao ; guiqiuzhao@126.com" class="auth_mail" title="E-mail the corresponding author ; Jing Lin ; Nan Jiang ; Cui Li ; Liting Hu ; Xudong Peng ; Qiang Xu ; Qian Wang ; Hui Li ; Yan Zhang
- 关键词：Surfactant protein D ; Fungal keratitis ; Toll-like receptor 4 ; Aspergillus fumigatus
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：433-439
- 全文大小：656 K
文摘
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SP-D can be stimulated by TLR4 during A. fumigatus infection in HCECs.
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Recombinant human SP-D can inhibit the expression of inflammatory cytokines.
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The immunosuppression function of SP-D may act through TLR4 signaling pathway.