Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats

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• 作者：Jianhua Liu^a ; Wenbin Fu^a ; Wei Yi^a ; Zhenhua Xu^a ; Yuan Liao^a ; Xinran Li^a ; Jiesi Chen^a ; Xuefang Liu^a ; Nenggui Xu ; ^a ; ^{ngxu8018@gzhtcm.edu.cn}
• 关键词：Finance ; Asset pricing ; Information
• 刊名：Brain Research
• 出版年：2011
• 出版时间：10 February 2011
• 年：2011
• 卷：1373
• 期：Complete
• 页码：160-171
• 全文大小：2406 K

文摘

Acupuncture has been applied in the clinic to treat visceral pain for a long time. However, the underlying mechanism still remains unknown. In the present study, extrasegmental analgesia of electroacupuncture (EA) at orofacial acupoints on visceral pain rats was investigated. The results revealed that nociceptive EA stimulation applied at heterotopic acupoints or nonacupoints to activate A_δ and/or C fibers induced c-fos expression in the paratrigeminal nucleus (PTN) and significantly inhibited acetic acid-induced abdominal contractions and c-fos expression in the nucleus of the solitary tract (NTS). However, non-nociceptive EA or non-EA stimulation applied at heterotopic acupoints was totally ineffective. After infraorbital nerves transaction or pretreated by capsaicin, the EA analgesia was dramatically inhibited. Snake venom pretreatment had no influence on this analgesia. Consequently, heterotopic EA stimulation trigger the pain-inhibiting effect of diffuse noxious inhibitory controls (DNIC), in which PTN–NTS secondary neural pathway may be involved and small-diameter (A_δ and/or C) fibers are crucial.