Efficacy and safety of adjunctive lacosamide for the treatment of partial-onset seizures in Chinese and Japanese adults: A randomized, double-blind, placebo-controlled study
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- 作者：Zhen Honga ; 1 ; profzhong@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yushi Inoueb ; 1 ; yshinoue@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Weiping Liaoc ; wpliao@163.net" class="auth_mail" title="E-mail the corresponding author ; Hongmei Mengd ; hongmeiyp@126.com" class="auth_mail" title="E-mail the corresponding author ; Xuefeng Wange ; xfyp@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenmin Wangf ; wmw85@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Liemin Zhoug ; lmzhou56@163.com" class="auth_mail" title="E-mail the corresponding author ; Liming Zhangh ; zfx001@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xinlu Dui ; Xinlu.Du@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Frank Tennigkeitj ; Frank.Tennigkeit@ucb.com" class="auth_mail" title="E-mail the corresponding author ; on behalf of the EP0008 Study Group
- 关键词：AE ; adverse event ; AED ; antiepileptic drug ; CV% ; coefficient of variation ; ECG ; electrocardiogram ; FAS ; full analysis set ; ITT ; intent-to-treat ; OR ; odds ratio ; PK ; pharmacokinetic ; POS ; focal (partial-onset) seizures ; PK-PPS ; pharmacokinetic per-protocol set ; SD ; standard deviation ; SS ; safety set ; TEAE ; treatment-emergent adverse event
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：267-275
- 全文大小：927 K
文摘
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Efficacy and safety of lacosamide was evaluated in an exclusively Asian population.
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Greater median changes in POS frequency were observed with lacosamide vs placebo.
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Significant percent reductions in seizure frequency over placebo were observed.
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Safety data in this Asian population were consistent with previous pivotal studies.