An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling
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- 作者：Arunachalam Vinayagam1 ; 8 ; Meghana M. Kulkarni1 ; 8 ; 9 ; Richelle Sopko1 ; Xiaoyun Sun2 ; Yanhui Hu1 ; 3 ; Ankita Nand3 ; 4 ; Christians Villalta1 ; Ahmadali Moghimi1 ; Xuemei Yang5 ; 6 ; Stephanie E. Mohr1 ; 3 ; Pengyu Hong2 ; John M. Asara5 ; 6 ; Norbert Perrimon1 ; 7 ; 10 ; perrimon@receptor.med.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：3062-3074
- 全文大小：6449 K
文摘
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The dynamic protein-protein interaction network around the insulin pathway is mapped
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Half of the network components are validated using RNAi screens
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Approximately 10% of interacting proteins are phospho-regulated by insulin stimulation
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PP2A and Reptin-Pontin modulate the insulin pathway