Highly efficient synthesis of 2,3,4-trisubstituted furans via silver-catalyzed sequential nucleophilic addition and cyclization reactions of haloalkynes
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- 作者：Wei Zeng ; Wanqing Wu ; Huanfeng Jiang ; Yadong Sun ; Zhengwang Chen
- 关键词：Furan ; Silver ; Haloalkynes ; Nucleophilic addition ; Cyclization
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：28 August, 2013
- 年：2013
- 卷：54
- 期：35
- 页码：4605-4609
- 全文大小：810 K
文摘
A regioselective synthesis of 2,3,4-trisubstituted furans using AgNO3 catalyst from haloalkynes in a one-pot procedure has been reported. The transformation consists of a sequential silver-catalyzed nucleophilic addition and cyclization reaction of haloalkynes. A wide variety of haloalkynes can be used in this chemical process.