The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma
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- 作者：Yajun Wang ; Huiting Hu ; Jun Wu ; Xuanna Zhao ; Yan Zhen ; Shaobing Wang ; Wen Li ; Min Liang ; Bin Wu ; wubin621011@126.com" class="auth_mail" title="E-mail the corresponding author ; Guoda Ma ; sihan1107@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：sIL-6R ; soluble IL-6 receptor ; IgE ; immunoglobulin E ; IL-6 ; interleukin 6 ; mIL-6R ; membrane-bound IL-6 receptor ; SNP ; single nucleotide polymorphism ; ELISA ; enzyme-linked immunosorbent assay ; PCR ; polymerase chain reaction ; HWE ; Hardy&ndash ; Weinberg equilibrium ; FEV1 ; the forced expiratory volume in 1 second ; ppFEV1 ; percent predicted FEV1 ; ppFVC ; percent predicted forced vital capacity ; FEF 25&ndash ; 27% ; the average forced expiratory flow during the mid (25&ndash ; 75%) portion of the FVC ; MAF ; m
- 刊名：Gene
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：585
- 期：1
- 页码：51-57
- 全文大小：512 K
文摘
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Serum sIL-6R increased in serum of patients with asthma, the elevated sIL6R correlated with higher IgE and lower FEV1
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IL6R polymorphism rs2228145 C allele related to higher sIL6R, higher serum IgE levels and lower lung functions in patients with asthma
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IL6R polymorphism rs12083537 G allele associated with lower lung functions in patients with asthma